|
T13950 |
UC-514321
|
|
Apoptosis
,
STAT
|
|
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. |
|
T12253 |
Nrf2-IN-1
|
|
Others
,
Nrf2
|
|
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). |
|
T7138 |
FB23-2
|
|
Apoptosis
,
Others
|
|
FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM). |
|
T12943 |
SNDX-5613
|
|
Epigenetic Reader Domain
,
Histone Methyltransferase
|
|
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias. |
|
T9041 |
AES-350
|
|
Apoptosis
,
HDAC
|
|
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ... |
|
T9014 |
SKI-178
|
|
Apoptosis
,
S1P Receptor
|
|
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ... |
|
T8882 |
Vodobatinib
|
K-0706 |
Bcr-Abl
|
|
Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity. |
|
T64338 |
AKI603
|
AKI 603,AKI-603 |
Aurora Kinase
|
|
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l... |
|
T24269 |
KPT-251
|
KPT251 |
Others
|
|
KPT-251 is a selective nuclear export inhibitor. |
|
T16557 |
PNU-159682
|
|
Topoisomerase
|
|
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin. |
|
T14919 |
CDKI-73
|
|
Apoptosis
,
CDK
|
|
CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effe... |
|
T9705 |
TL-895
|
|
BTK
|
|
TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM. |
|
T10606 |
BRD0705
|
|
GSK-3
|
|
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM). |
|
T38562 |
AKN-028
|
|
FLT
|
|
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation. |
|
T2620 |
G-749
|
G749 |
Apoptosis
,
FLT
,
c-RET
,
TAM Receptor
,
Aurora Kinase
|
|
G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants. |
|
T28475 |
Pyrazoloacridine
|
PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 |
Apoptosis
,
Topoisomerase
|
|
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity. |
|
T10384 |
Farudodstat
|
ASLAN003 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
|
|
Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML. |
|
T22553 |
Adaphostin
|
1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410 |
Bcr-Abl
|
|
Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM. |
|
T8978 |
DD1
|
3,3'-Diamino-4'-methoxyflavone,HUN85111 |
Proteasome
|
|
DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis. |
|
T3184 |
Kevetrin hydrochloride
|
Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride |
Mdm2
,
p53
|
|
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. |
|
T1979 |
AVN-944
|
VX-944 |
Dehydrogenase
|
|
AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. |
|
T2066 |
Quizartinib
|
AC220 |
Apoptosis
,
FLT
,
Autophagy
,
Ligands for Target Protein for PROTAC
|
|
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. |
|
T0942 |
Quinacrine dihydrochloride
|
Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl |
Apoptosis
,
Mitophagy
,
DNA
,
Phospholipase
,
Parasite
,
Autophagy
,
Histamine Receptor
|
|
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. |
|
T2346L |
Enasidenib mesylate
|
AG221 mesylate,AG 221 mesylate,AG-221 mesylate |
Dehydrogenase
|
|
Enasidenib mesylate (AG-221 mesylate) is a potent and selective IDH2 mutase inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia. |
|
T27299 |
F-14512 (free base)
|
F14512,F-14512 |
|
|
F-14512, a DNA topoisomerase II inhibitor, is used potentially for the treatment of acute myeloid leukemia. |
|
T12629L |
MIK665
|
S-64315 |
BCL
|
|
MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia. |
|
T25006 |
AGI-14100
|
AGI 14100 |
Dehydrogenase
|
|
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia. |
|
T3099 |
Pinometostat
|
EPZ-5676 |
Histone Methyltransferase
|
|
Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others. |
|
T6857 |
HLCL-61 hydrochloride
|
HLCL61,HLCL-61 HCL |
Apoptosis
,
Histone Methyltransferase
|
|
HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
|
T9749 |
FHD-286
|
|
Epigenetic Reader Domain
|
|
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia. |
|
T9843 |
FLT3-IN-16
|
|
|
|
FLT3-IN-16 exhibits potent inhibitory activity against FLT3 tyrosine kinase with an IC 50 of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia [1]. |
|
T13519 |
6-Aminochrysene
|
6-Chrysenamine |
Others
|
|
6-Aminochrysene (6-Chrysenamine) is an inhibitor of the growth of several solid experimental tumors and can be used in studies about splenomegaly, breast cancer and myeloid leukemia. |
|
T83966 |
LSD1-IN-30
|
|
Histone Demethylase
|
|
LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia. |
|
T9060 |
STM2457
|
|
Apoptosis
,
Others
|
|
STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies. |
|
T6916 |
OICR-9429
|
OICR 9429 |
Histone Methyltransferase
,
JAK
|
|
OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro. |
|
T83630 |
STM3006
|
|
Others
|
|
STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML). |
|
T60081 |
BV02
|
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid |
Others
|
|
BV02 is an inhibitor of 14-3-3 protein-protein interactions and can be used in studies about the treatment of chronic myeloid leukemia. BV02 disrupts hematopoietic cells expressing the IM-resistant T315I mutation and the... |
|
T17065 |
TFMB-(R)-2-HG
|
|
Others
|
|
TFMB-(R)-2-HG is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cell differentiation in response to estrogen withdrawal. |
|
T9175 |
Casein Kinase inhibitor A51
|
|
Apoptosis
,
Casein Kinase
|
|
Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, b... |
|
T12040 |
Milademetan
|
RAIN-32,DS-3032,DS3032b |
Mdm2
,
Others
|
|
|
|
T4409 |
Gilteritinib
|
ASP2215 |
FLT
,
TAM Receptor
,
c-Kit
|
|
Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an... |
|
T79404 |
A09-003
|
|
Apoptosis
,
BCL
,
CDK
|
|
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.A0... |
|
TP1115 |
L-Asparaginase
|
L-ASNase |
Others
|
|
L-Asparaginase (L-ASNase) (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment.Asparaginase is an enzyme that is used as a medication. As a medication, L-a... |
|
T10608 |
BRD5648
|
(R)-BRD0705 |
GSK-3
|
|
|
|
T10799 |
CHMFL-ABL-039
|
|
Bcr-Abl
|
|
CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor (IC50s: 7.9 nM and 27.9 nM) used in the research of chronic myeloid leukemia. |
|
T9856 |
FLT3-IN-10
|
2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl- |
FLT
|
|
FLT3-IN-10 (2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl-) (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 shows the potential for the treatment of FLT3-mutated acute myeloid leukemia (... |
|
T60364 |
DHODH-IN-17
|
|
Dehydrogenase
|
|
DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemia (AML). |
|
T9707 |
DB2313
|
Carboximidamide |
Apoptosis
|
|
|
|
T27011 |
CHMFL-FLT3-122
|
CHMFLFLT3122,CHMFL FLT3 122 |
FLT
|
|
CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft m... |
|
T76794 |
Ulocuplumab
|
BMS 936564,MDX 1338 |
Apoptosis
,
CXCR
|
|
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplu... |
